Wednesday, February 17, 2016

Going Nuts for Oral Immunotherapy



               Americans eat an estimated total of seven hundred million pounds of peanut butter every year.  However, about three million Americans are unable to consume peanut butter or any products containing peanuts due to peanut allergies.  Even though it seems impossible for these people to ever have peanut products, new research is experimenting with oral immunotherapy.  Said oral immunotherapy would slowly and increase these people’s tolerance to peanuts in a safe way.
               A trial to test the oral immunotherapy with peanut allergies was tested on ninety-nine children between the ages of seven and sixteen.  This trial took place for six months and had a placebo control.  The researchers first tested to see the patient’s threshold for the allergy.  The patients were then given a small dose, obviously lower than what their allergy reacts to and did this every day.  After two weeks of continuing this, they would increase the amount.  This trend would continue up until being increased nine times.  After twenty-six weeks, eighty-four percent of the patients were able to consume five peanuts a day while sixty-two percent could tolerate up to ten peanuts a day.
               Although results seem promising and beneficial in the patients’ allergies, the oral immunotherapy concept has yet to be approved by the U.S. Food and Drug Administration.  Even though the thought of people being able to “grow out” of their peanut allergy, it is also a scary idea as well.  The doctors have urged parents not to do this at home but of course, I am sure there will be many cases of parents and children trying to do the oral immunotherapy at home and on their own without doctor’s orders or supervision.  The oral immunotherapy would be beneficial because the amount of peanuts consumed would be less than the needed to agitate the symptoms in the patient, therefore causing no harm.  However, if parents do this at home, they will not know the necessary limit for their child and have a high chance of accidently going over their child’s limit.
               Also, although this is under the supervision of doctors, the oral immunotherapy may not always work for all patients.  Some of the patients may still have side effects or reactions as they increase their daily peanut dosage, resulting in not fun side effects.  Also, in order to have a set amount for daily intake, the doctors must test the patients to see their threshold which in result would give them the stomach troubles, rashes, breathing irritations, etc. that they avoid by not eating peanuts.  It’s a hard concept to grasp: whether to possibly put your child in harms’ way in order to make their life a little easier in the long run or go along with the allergy and the pains of not being able to eat certain foods.

"Peanut Facts - Texas Peanut Producers Board." Texas Peanut Producers Board. Texas Peanut Producers, 2016. Web. 17 Feb. 2016.
Sicherer, S. H. "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, Apr. 1999. Web. 17 Feb. 2016.
Kwan, Nicole. "Oral Immunotherapy for Peanut Allergies Shows Promise, Study Finds | Fox News." Fox News. FOX News Network, 30 Jan. 2014. Web. 17 Feb. 2016.

6 comments:

  1. It was interesting to see how this related to the talk that we had in class the other day about immunology. I personally do not have any known allergies, but I am sure that potentially being able to get rid of your allergies would be life changing for some.

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  2. I agree with Josiah. It was interesting that your blog post directly related to the discussion about immunology and Dr. Kottyan's upcoming research about allergies. This advancement in oral immunology is great! There are a lot of people who suffer from allergies, peanut allergies especially. I feel that within the next year or so, oral immunotherapy will be polished and parents would be more willing to try this method for helping their kids with their allergy problems.

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  3. I am thankful to not be currently allergic to anything and even I see the huge significance in these findings! You could possibly be curing allergies by simple immunotherapy. I don't see why someone wouldn't want to pursue this option, because the risk, when polished up, are minuscule. The end results can be life-changing!

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  4. I read your post after asking Dr. Kottyan about this very same question! I never knew that this treatment was being used in practice. This treatment makes a lot of sense to me, and it's encouraging for me to think that science isn't all about being the most brilliant and knowledgable. Sometimes it's just about being innovative and thinking outside the box - like feeding a child with an allergy a peanut a day.

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  5. Even if the child can never eat peanuts or some other allergen without experiencing some form of reaction, an effort could be made to increase their tolerance. Many kids have life threatening peanuts allergies, so if the severity of this reaction could be decreased, then their lives would be a lot safer.

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  6. Immunotherapy such as allergy shots have been proven to decease allergic reactions. Oral immunotherapy allows this to happen easier with food allergies. This could potentially help all food allergies from shellfish to peanuts. Treatment of this would lessen severe anaphylactic reactions in patients and possibly allow them to enjoy some of the "forbidden food". Of course, all medical therapy should be monitored by professionals.

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